Data from 31 people indicated that that annatto tocotrienol – composed mainly of delta-tocotrienol – was associated with improvements in a number of cardiovascular risk factors including inflammatory cytokines, nitric oxide (NO) and C-reactive protein (CRP). Writing in the Journal of Clinical & Experimental Cardiology​​researchers from the University of Missouri – Kansas City reported that four weeks of eating a healthy diet and vitamin E tocotrienol supplementation at doses ranging from 125 to 750 mg/day decreased inflammatory and oxidative stress markers significantly. “These results suggest that delta-tocotrienol is a potential candidate for therapeutic applications in the maintenance of health and protection from aging diseases,”​ concluded the researchers, led by Prof. Asaf Qureshi. Vitamin E is a family of eight separate but related molecules: four tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta, gamma, delta). While alpha-tocopherol is found in most multivitamins and is supplemented in foods, a growing base of evidence suggests that this popular vitamin E interferes with the uptake and function of tocotrienols. Tocotrienols are derived from ...